Initially in this talk, the fabrication of an all-printed and flexible biosensor for antioxidants will be described in order to illustrate the techniques and approaches explored by our group in the field of printed bioelectronics [1]. The research work comprised the following steps: i) formulation of an enzyme-containing bioink with both good printability in the large-area, roll-to-roll (R2R) compatible, rotogravure printing method, and preserved catalytic activity after printing; ii) deposition of sub-100 µm Au interdigitated electrodes by inkjet printing; iii) deposition of large-area, patterned, bioactive films onto flexible substrates (PET and PEN); iv) testing of the all-printed device in electrical impedance biosensing. In a second moment, results from two other projects will be discussed. The first project comprises the fabrication of flexible inkjet-printed Au circuits that were used as a biomedical device for the early detection of pressure ulcers on skin [2]. The second project is a current initiative from our group in which electronic components (printed resistor, capacitor and transistor) are being deposited exclusively by inkjet-printing. These components will be further combined to build more complex devices as inverters and (in the long-term) all-printed, low-cost, RFID tags. In general, the aim of the presentation is to illustrate capabilities and interest from the Bernhard Gross Polymer Group in the area of Printed (Bio)Electronics.
References
[1] PAVINATTO, F. J.; PASCHOAL, C. W. A.; ARIAS, A. C. Printed and flexible biosensor for antioxidants using interdigitated ink-jetted electrodes and gravure-deposited active layer. Biosensors and Bioelectronics, v. 67, p. 553-559, 2015.
[2] SWISHER, S. L, LIN, M. C.; LIAO, A.; LEEFLANG, E. J.; KHAN, Y.; PAVINATTO, F. J.; MANN, K.; NAUJOKAS, A.; YOUNG, D.; ROY, S.; HARRISON, M. R.; ARIAS, A. C.; SUBRAMANIAN, V.; MAHARBIZ, M. Impedance sensing device enables early detection of pressure ulcers in vivo. Nature Communications, Accepted for Publication, 2015.
