Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA.
TEIXEIRA, Tamara; RIBEIRO, Gabriel Henrique; GONÇALVES, Guilherme Resende; HONORATO, João; OLIVEIRA, Katia Mara; CORRÊA, Rodrigo Souza.
TEIXEIRA, Tamara; RIBEIRO, Gabriel Henrique; GONÇALVES, Guilherme Resende; HONORATO, João; OLIVEIRA, Katia Mara; CORRÊA, Rodrigo Souza.
Abstract: New ruthenium(II) complexes bearing benzoate (AB) ligand with the general formula [Ru(AB)(bipy)(Psingle bondP)]PF6, where 2,2'-bipyridine (bipy) and different diphosphine ligands, (Psingle bondP) = 1,2'-bis(diphenylphosphine)ethane (dppe, 1), 1,3'-bis(diphenylphosphine)propane (dppp, 2) and 1,2'-bis(diphenylphosphine)ferrocene (dppf, 3), were synthesized. The compounds were characterized by molar conductivity, elemental analysis, cyclic voltammetry, infrared and UV-Vis spectroscopies, NMR, and by single-crystal X-ray diffraction for complexes 1 and 2. The complexes showed a weak interaction to CT-DNA through DNA minor groove, with Kb values at around 103-104 M-1. CT-DNA interaction assays by viscosity and circular dichroism (CD) suggested that the compounds do not significantly alter the secondary DNA structure. The complexes are cytotoxic against MDA-MB-231, MCF-7 (breast) and A549 (lung) tumor cell lines, with IC50 values in the range of 1 to 17 µM. The compounds 1-3 showed high selectivity against triple-negative breast tumor cells. Remarkably, complexes 1 and 3 show greater cytotoxic activity against cells than cisplatin, being promising agents for tumor treatment.
@article={003193912,author = {TEIXEIRA, Tamara; RIBEIRO, Gabriel Henrique; GONÇALVES, Guilherme Resende; HONORATO, João; OLIVEIRA, Katia Mara; CORRÊA, Rodrigo Souza.},title={Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA},journal={Inorganica Chimica Acta},note={v. 568, p. 122078-1-122078-10 + supplementary data 1-3},year={2024}}