Photodynamic therapy for nodular basal cell carcinoma up to 5mm located on high-risk area: effectiveness and long-term follow-up results.
SÁLVIO, Ana Gabriela; REQUENA, Michelle Barreto; AZEVEDO, Mirian Denise Stringasci de; FREGOLENTI, Bianca Antonelli; MEDEIRO, Maira Monique Da Costa; SILVA, Rosilene Guedes Santos; BAGNATO, Vanderlei Salvador.
SÁLVIO, Ana Gabriela; REQUENA, Michelle Barreto; AZEVEDO, Mirian Denise Stringasci de; FREGOLENTI, Bianca Antonelli; MEDEIRO, Maira Monique Da Costa; SILVA, Rosilene Guedes Santos; BAGNATO, Vanderlei Salvador.
Abstract: Significance: Response rates evaluation of photodynamic therapy (PDT) for nodular basal cell carcinoma (BCC) treatment located on high-risk and low-risk areas of the face. Approach: Two groups of nodular BCC were selected, debulked, and received 20% methyl aminolevulinate (MAL) hydrochloride cream. After 3 h, the first irradiation was performed (20 min, 150 J/cm2). Then, the cream was re-applied, and a second irradiation was performed after 1.5 h (20 min, 150 J/cm2). Clearance at 30 days and recurrence-free survival rate were evaluated. Results: The clearance at 30 days after PDT was 89% for the low-risk area group and 87% for the high-risk group. The recurrence-free survival at 60 months was 82% and 85% for the high-risk and low-risk groups, respectively. Conclusions: No significant differences were observed between groups nor for clearance at 30 days, nor recurrence-free follow-up. These results make PDT possible option for nodular BCC less than 5 mm located in high-risk areas.
@article={003182491,author = {SÁLVIO, Ana Gabriela; REQUENA, Michelle Barreto; AZEVEDO, Mirian Denise Stringasci de; FREGOLENTI, Bianca Antonelli; MEDEIRO, Maira Monique Da Costa; SILVA, Rosilene Guedes Santos; BAGNATO, Vanderlei Salvador.},title={Photodynamic therapy for nodular basal cell carcinoma up to 5mm located on high-risk area: effectiveness and long-term follow-up results},journal={Photodiagnosis and Photodynamic Therapy},note={v. 45, p. 103919-1-103919-3},year={2024}}