SuFEx-functionalized quinones via ruthenium-catalyzed C-H alkenylation: a potential building block for bioactivity valorization.
OLIVEIRA, Joyce Cristina de; ABREU, Breno Urcine; PAZ, Esther Regina Silva; ALMEIDA, Renata Gomes de; ARAUJO NETO, João Honorato; SOUZA, Cauê Paula de; FANTUZZI, Felipe; RAMOS, Victor F. S.; MENNA-BARRETO, Rubem Figueiredo Sadok; ARAUJO, Maria Helena; JARDIM, Guilherme Augusto de Melo; SILVA JÚNIOR, Eufrânio Nunes da.
OLIVEIRA, Joyce Cristina de; ABREU, Breno Urcine; PAZ, Esther Regina Silva; ALMEIDA, Renata Gomes de; ARAUJO NETO, João Honorato; SOUZA, Cauê Paula de; FANTUZZI, Felipe; RAMOS, Victor F. S.; MENNA-BARRETO, Rubem Figueiredo Sadok; ARAUJO, Maria Helena; JARDIM, Guilherme Augusto de Melo; SILVA JÚNIOR, Eufrânio Nunes da.
Abstract: Herein, we describe the Ru-catalyzed C-H alkenylation of 1,4-naphthoquinones (1,4-NQs), resulting in 1,4-naphthoquinoidal/SuFEx hybrids with moderate to good yields. This method provides a novel route for direct access to ethenesulfonyl-fluorinated quinone structures. We conducted mechanistic studies to gain an in-depth understanding of the elementary steps of the reaction. Additionally, we evaluated the prototypes against trypomastigote forms of T. cruzi, leading to the identification of compounds with potent trypanocidal activity..
@article={003237094,author = {OLIVEIRA, Joyce Cristina de; ABREU, Breno Urcine; PAZ, Esther Regina Silva; ALMEIDA, Renata Gomes de; ARAUJO NETO, João Honorato; SOUZA, Cauê Paula de; FANTUZZI, Felipe; RAMOS, Victor F. S.; MENNA-BARRETO, Rubem Figueiredo Sadok; ARAUJO, Maria Helena; JARDIM, Guilherme Augusto de Melo; SILVA JÚNIOR, Eufrânio Nunes da.},title={SuFEx-functionalized quinones via ruthenium-catalyzed C-H alkenylation: a potential building block for bioactivity valorization},journal={Chemistry - An Asian Journal},note={v. 19, n. 22, p. e202400757},year={2024}}