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SuFEx-functionalized quinones via ruthenium-catalyzed C-H alkenylation: a potential building block for bioactivity valorization.
OLIVEIRA, Joyce Cristina de; ABREU, Breno Urcine; PAZ, Esther Regina Silva; ALMEIDA, Renata Gomes de; ARAUJO NETO, João Honorato; SOUZA, Cauê Paula de; FANTUZZI, Felipe; RAMOS, Victor F. S.; MENNA-BARRETO, Rubem Figueiredo Sadok; ARAUJO, Maria Helena; JARDIM, Guilherme Augusto de Melo; SILVA JÚNIOR, Eufrânio Nunes da.
Abstract: Herein, we describe the Ru-catalyzed C-H alkenylation of 1,4-naphthoquinones (1,4-NQs), resulting in 1,4-naphthoquinoidal/SuFEx hybrids with moderate to good yields. This method provides a novel route for direct access to ethenesulfonyl-fluorinated quinone structures. We conducted mechanistic studies to gain an in-depth understanding of the elementary steps of the reaction. Additionally, we evaluated the prototypes against trypomastigote forms of T. cruzi, leading to the identification of compounds with potent trypanocidal activity..
Chemistry - An Asian Journal
v. 19, n. 22, p. e202400757 - Ano: 2024
Fator de Impacto: 3,5
    @article={003237094,author = {OLIVEIRA, Joyce Cristina de; ABREU, Breno Urcine; PAZ, Esther Regina Silva; ALMEIDA, Renata Gomes de; ARAUJO NETO, João Honorato; SOUZA, Cauê Paula de; FANTUZZI, Felipe; RAMOS, Victor F. S.; MENNA-BARRETO, Rubem Figueiredo Sadok; ARAUJO, Maria Helena; JARDIM, Guilherme Augusto de Melo; SILVA JÚNIOR, Eufrânio Nunes da.},title={SuFEx-functionalized quinones via ruthenium-catalyzed C-H alkenylation: a potential building block for bioactivity valorization},journal={Chemistry - An Asian Journal},note={v. 19, n. 22, p. e202400757},year={2024}}