Abstract – Publication

Bidentate coordination of 2-aminopyridine (2Apy) in cis-[Ru(phen)2(2Apy)]2+ aiming at photobiological studies.
LIMA, Marcia V. S.; MARCHI, Rafael C.; CARDOSO, Carolina R.; COOK, Nathan P.; PAZIN, Wallance Moreira; KOCK, Flavio V. C.; VENÂNCIO, Tiago; MARTÍ, Angel A.; CARLOS, Rose M.
Abstract: This study describes the synthesis and characterization of the photoluminescent and water-soluble complex cis-[Ru(phen)2(2Apy)]2+ (Ru2Apy, phen=1,10-phenanthroline and 2Apy=2-aminopyridine), which exhibits spectroscopic and physicochemical properties favorable for biological applications. 1H-NMR, photoluminescence, and UV-vis spectroscopy experiments show bidentate coordination of the 2Apy ligand, which leads to a blue shift in the emission spectrum and places the 3MLCT in proximity to the 3MC excited states, thus enabling a photochemical pathway. Under continuous light irradiation at 450 nm, Ru2Apy opens the coordinating site of the NH2 group in 2Apy to form the monoacetonitrile complex cis-[Ru(phen)2(2Apy)(CH3CN))2+, with a quantum yield of 0.457. Further irradiation leads to a second photoprocess to form the bis-acetonitrile cis-[Ru(phen)2(CH3CN)2]2+ complex, with a quantum yield of 0.002. Ru2Apy binds to human serum albumin via non-covalent interactions with Kb=4.63×10-9 mol?L-1, ?H=-3.4×10-3 kcal?mol-1, and ?S=8.7 kcal?mol-1K-1, and displays a moderate inhibition of AChE with an IC50 of 13.2±2.0 µmol?L-1. The complex also exhibited high uptake into HeLa cells with no cytotoxicity. Furthermore, the emissive response of Ru2Apy was be used to assess, in real-time, the aggregation of Aß1-40 in a dose-dependent manner.
European Journal of Inorganic Chemistry
v. 2022, n. 11, p. e202101015-1-e202101015-9 + supporting information: S1-S13 - Ano: 2022
Fator de Impacto: 2,524
    @article={003072536,author = {LIMA, Marcia V. S.; MARCHI, Rafael C.; CARDOSO, Carolina R.; COOK, Nathan P.; PAZIN, Wallance Moreira; KOCK, Flavio V. C.; VENÂNCIO, Tiago; MARTÍ, Angel A.; CARLOS, Rose M.},title={Bidentate coordination of 2-aminopyridine (2Apy) in cis-[Ru(phen)2(2Apy)]2+ aiming at photobiological studies},journal={European Journal of Inorganic Chemistry},note={v. 2022, n. 11, p. e202101015-1-e202101015-9 + supporting information: S1-S13},year={2022}}

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