Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS.
SILVA, Francine Cristina da; ROSA, Luciano Pereira; SANTOS, Gabriel de Pinto de Oliveira; INADA, Natalia Mayumi; BLANCO, Kate Cristina; ARAÚJO, Thalita Santos Dantas; BAGNATO, Vanderlei Salvador.
SILVA, Francine Cristina da; ROSA, Luciano Pereira; SANTOS, Gabriel de Pinto de Oliveira; INADA, Natalia Mayumi; BLANCO, Kate Cristina; ARAÚJO, Thalita Santos Dantas; BAGNATO, Vanderlei Salvador.
Abstract: Objectives To test the effectiveness of an efficient therapeutic protocol for the total mouth antimicrobial photodynamic therapy (aPDT) mediated by 450 nm blue LED associated with curcumin in individuals with AIDS. Methods Patients were selected by exclusion criteria and randomly distributed in groups to test the effectiveness of antimicrobial aPDT with curcumin 0.75 mg/mL associated with the blue LED (67 mW/cm2, 20.1 J/cm2). Before and after the treatments, samples were collected from the saliva being processed in duplicate in selective culture media. The colonies were counted and the results obtained in log10 CFU/mL were statistically tested (T-paired statistical test, 5%). Results The log10 CFU/mL of Streptococcus spp., Staphylococcus spp., and total count of microorganisms showed statistically significant (p = 0.023; p = 0.001 and p = 0.017, respectively) reduction after treatment in patients with aPDT. Conclusion aPDT was effective in reducing Streptococcusspp. in addition to reducing Staphylococcusspp., enterobacteria and the total count of microorganisms when considering the numbers of TCD4 and TCD8 lymphocytes. The aPDT in the studied protocol was able to control clinically important intraoral microorganisms for AIDS patients, both those with TCD4 lymphocytes above or below 25% of normal and those with TCD8 lymphocytes above 25% of normal.
@article={003001404,author = {SILVA, Francine Cristina da; ROSA, Luciano Pereira; SANTOS, Gabriel de Pinto de Oliveira; INADA, Natalia Mayumi; BLANCO, Kate Cristina; ARAÚJO, Thalita Santos Dantas; BAGNATO, Vanderlei Salvador.},title={Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS},journal={Expert Review of Anti-infective Therapy},note={v. 18, n. 7, p. 689-696},year={2020}}