Abstract

Green one-pot asymmetric synthesis of peptidomimetics via sequential organocatalyzed aziridination and Passerini multicomponent reaction.
SANTOS, Deborah A.; SILVA, Allan R.; ELLENA, Javier; SILVA, Cecilia C. P.; PAIXÃO, Marcio W.; CORRÊA, Arlene G.
Abstract: Peptidomimetics containing an aziridine moiety have been reported as potent cysteine protease inhibitors. In this sense, the development of stereoselective and sustainable synthetic strategies to obtain threemembered N-heterocyclic compounds has gained importance in the last decades. In this work, an efficient method was designed to achieve highly functionalized aziridine peptidomimetics via a sequential reaction, which involves the organocatalytic aziridination of a,ß-unsaturated aldehydes followed by the Passerini multicomponent reaction in an environmentally friendly solvent mixture (ethanol: water).
Synthesis
v. 52, n. 7, p. 1076-1086 - Ano: 2020
Fator de Impacto: 2,867
    @article={002994222,author = {SANTOS, Deborah A.; SILVA, Allan R.; ELLENA, Javier; SILVA, Cecilia C. P.; PAIXÃO, Marcio W.; CORRÊA, Arlene G.},title={Green one-pot asymmetric synthesis of peptidomimetics via sequential organocatalyzed aziridination and Passerini multicomponent reaction},journal={Synthesis},note={v. 52, n. 7, p. 1076-1086},year={2020}}

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