Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion.
GALASSO, Marcos; FELD, Jordan J.; WATANABE, Yui; PIPKIN, Mauricio; SUMMERS, Cara; ALI, Aadil; QAQISH, Robert; CHEN, Manyin; RIBEIRO, Rafaela V. P.; RAMADAN, Khaled; PIRES, Layla; BAGNATO, Vanderlei Salvador; KURACHI, Cristina; CHEREPANOV, Vera; MOONEN, Gray; GAZZALLE, Anajara; WADDELL, Thomas K.; LIU, Mingyao; KESHAVJEE, Shaf; WILSON, Brian C.; HUMAR, Atul; CYPEL, Marcelo.
GALASSO, Marcos; FELD, Jordan J.; WATANABE, Yui; PIPKIN, Mauricio; SUMMERS, Cara; ALI, Aadil; QAQISH, Robert; CHEN, Manyin; RIBEIRO, Rafaela V. P.; RAMADAN, Khaled; PIRES, Layla; BAGNATO, Vanderlei Salvador; KURACHI, Cristina; CHEREPANOV, Vera; MOONEN, Gray; GAZZALLE, Anajara; WADDELL, Thomas K.; LIU, Mingyao; KESHAVJEE, Shaf; WILSON, Brian C.; HUMAR, Atul; CYPEL, Marcelo.
 Abstract: Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development. | |
| Nature Communications |
| v. 10, p. 481-1-481-12 - Ano: 2019 |
| Fator de Impacto: 12,353 |
| http://dx.doi.org/10.1038/s41467-018-08261-z |  @article={002923856,author = {GALASSO, Marcos; FELD, Jordan J.; WATANABE, Yui; PIPKIN, Mauricio; SUMMERS, Cara; ALI, Aadil; QAQISH, Robert; CHEN, Manyin; RIBEIRO, Rafaela V. P.; RAMADAN, Khaled; PIRES, Layla; BAGNATO, Vanderlei Salvador; KURACHI, Cristina; CHEREPANOV, Vera; MOONEN, Gray; GAZZALLE, Anajara; WADDELL, Thomas K.; LIU, Mingyao; KESHAVJEE, Shaf; WILSON, Brian C.; HUMAR, Atul; CYPEL, Marcelo.},title={Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion},journal={Nature Communications},note={v. 10, p. 481-1-481-12},year={2019}} |
