Investigation of the triplet excited state and application of cationic meso-tetra(cisplatin)porphyrins in antimicrobial photodynamic therapy.
JORNADA, Dariane Clerici; GARCIA, Rafael de Queiroz; SILVEIRA, Carolina Hahnda; MISOGUTI, Lino; MENDONÇA, Cleber Renato; SANTOS, Roberto Christ Vianna; DE BONI, Leonardo; IGLESIAS, Bernardo Almeida.
JORNADA, Dariane Clerici; GARCIA, Rafael de Queiroz; SILVEIRA, Carolina Hahnda; MISOGUTI, Lino; MENDONÇA, Cleber Renato; SANTOS, Roberto Christ Vianna; DE BONI, Leonardo; IGLESIAS, Bernardo Almeida.
Abstract: In this manuscript, we report, the photophysical study of triplet excited states and antimicrobial photoinactivation of positively charged tetra-cisplatin porphyrin derivatives against Gram + and Gram - bacterial strains. Isomeric cisplatin-porphyrins were used and applied in aPDT assays in the bacilli Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa (Gram negative) and a cocci Staphylococcus aureus (Gram positive) strains. The results show that compound substituted at meta position (3-cis-PtTPyP) is the more efficient photosensitizer against bacteria culture. In this way, tetra-cationic porphyrins containing cisplatin derivatives might be promising aPDT agents with potential applications in clinical infections.
@article={003037302,author = {JORNADA, Dariane Clerici; GARCIA, Rafael de Queiroz; SILVEIRA, Carolina Hahnda; MISOGUTI, Lino; MENDONÇA, Cleber Renato; SANTOS, Roberto Christ Vianna; DE BONI, Leonardo; IGLESIAS, Bernardo Almeida.},title={Investigation of the triplet excited state and application of cationic meso-tetra(cisplatin)porphyrins in antimicrobial photodynamic therapy},journal={Photodiagnosis and Photodynamic Therapy},note={v. 35, p. 102459-1-102459-9},year={2021}}