cis-bis(N-benzoyl-N0,N0-dibenzylthioureido) platinum(II): synthesis, molecular structure and its interaction with human and bovine serum albumin.
CORREA, Rodrigo S.; OLIVEIRA, Katia M.; PÉREZ, Hiram; PLUTÍN, Ana M.; RAMOS, Raúl; MOCELO, Raúl; CASTELLANO, Eduardo Ernesto; BATISTA, Alzir A.
CORREA, Rodrigo S.; OLIVEIRA, Katia M.; PÉREZ, Hiram; PLUTÍN, Ana M.; RAMOS, Raúl; MOCELO, Raúl; CASTELLANO, Eduardo Ernesto; BATISTA, Alzir A.
Abstract: In this paper, the title compound was synthesized from N-benzoyl-N0,N0-dibenzyl thiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X-ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N0,N0-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C-H C, C-H S and H H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M 1 and 104 M 1, respectively. Thermodynamic parameters (DG, DH and DS) suggest spontaneous interactions between complex and the proteins.
@article={002982816,author = {CORREA, Rodrigo S.; OLIVEIRA, Katia M.; PÉREZ, Hiram; PLUTÍN, Ana M.; RAMOS, Raúl; MOCELO, Raúl; CASTELLANO, Eduardo Ernesto; BATISTA, Alzir A.},title={cis-bis(N-benzoyl-N0,N0-dibenzylthioureido) platinum(II): synthesis, molecular structure and its interaction with human and bovine serum albumin},journal={Arabian Journal of Chemistry},note={v. 12, n. 8, p. 3454-3462},year={2019}}