IFSC NO YOUTUBE IFSC no Youtube | @ifscusp

  1. Home
  2. Resumo – Publicações

Resumo – Publicações

Antimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expression.
BORDINI, Ester Alves Ferreira; TONON, Caroline Coradi; FRANCISCONI, Renata Serignoli; MAGALHÃES, Fernando Augusto Cintra; HUACHO, Patrícia Milagros Maquera; BEDRAN, Telma Lombardo; PRATAVIEIRA, Sebastião; SPOLIDORIO, Luis Carlos; SPOLIDORIO, Denise Palomari.
Abstract: This study evaluated the antibacterial activity of terpinen-4-ol against Streptococcus mutans and Lactobacillus acidophilus and its influence on gbpA (S. mutans) and slpA (L. acidophilus) gene expression. As measured by XTT assay, the concentrations of terpinen-4-ol that effectively inhibited the biofilm were 0.24% and 0.95% for S. mutans and L. acidophilus, respectively. Confocal microscopy revealed the presence of a biofilm attached to the enamel and dentin block surfaces with significant terpinen-4-ol effects against these microorganisms. The expression of the gbpA and slpA genes involved in adherence and biofilm formation was investigated using RT-PCR. Expression of these genes decreased after 15 min with 0.24% and 0.95% terpinen-4-ol in S. mutans and L. acidophilus, respectively. These findings demonstrate the antimicrobial activity of terpinen-4-ol and its ability to modulate the expression of gbpA and slpA genes, emphasizing the therapeutic capacity of terpinen-4-ol as an alternative to inhibit adherence in biofilm.
Biofouling
v. 34, n. 7, p. 815-825 - Ano: 2018
Fator de Impacto: 2,786
http://dx.doi.org/10.1080/08927014.2018.1504926
    @article={002919313,author = {BORDINI, Ester Alves Ferreira; TONON, Caroline Coradi; FRANCISCONI, Renata Serignoli; MAGALHÃES, Fernando Augusto Cintra; HUACHO, Patrícia Milagros Maquera; BEDRAN, Telma Lombardo; PRATAVIEIRA, Sebastião; SPOLIDORIO, Luis Carlos; SPOLIDORIO, Denise Palomari.},title={Antimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expression},journal={Biofouling},note={v. 34, n. 7, p. 815-825},year={2018}}