Synthesis, structural characterization and biological evaluation of rhenium(I) tricarbonyl complexes with b-carboline ligands.
MAISULS, Iván; WOLCAN, Ezequiel; PIRO, Oscar E.; CASTELLANO, Eduardo Ernesto; PETROSELLI, Gabriela; ERRA-BALSELLS, Rosa; CABRERIZO, Franco M.; RUIZ, Gustavo T.
MAISULS, Iván; WOLCAN, Ezequiel; PIRO, Oscar E.; CASTELLANO, Eduardo Ernesto; PETROSELLI, Gabriela; ERRA-BALSELLS, Rosa; CABRERIZO, Franco M.; RUIZ, Gustavo T.
 Abstract: Two b-carboline rhenium(I) complexes, fac-[Re(CO)3 (dppz)(nHo)]O3SCF3 and fac-[Re(CO)3(nHo)2Cl] where dppz= dipyrido[3, 2-a:2?,3?-c] phenazine and nHo=9H-pyrido[3, 4-b] indole (norharmane), have been synthesized. These complexes were fully characterized by structural X-ray diffraction, 1H and 13CNMR, UV-vis absorption and FT-IR spectroscopy and mass spectrometry. Ground state geometry optimization was carried out in vacuo with the PBE0 hybrid functional using the LanL2DZ basis set. The characterization was complemented with TD-DFT calculations using several hybrid functionals. Cellular uptake and cytotoxic effect of both complexes against human lung carcinoma (A549) cells were evaluated. For comparative purpose, two related fac-[Re(CO)3(L)(nHo)]+ complexes (L=bpy and phen) were included in the biological studies. The anti-proliferative effect of the compounds was rationalized in terms of the different extension of the ligands psystem. | |
| Chemistry Select |
| v. 2, n. 27, p. 8666-8672 - Ano: 2017 |
| http://dx.doi.org/10.1002/slct.201701961 |  @article={002854194,author = {MAISULS, Iván; WOLCAN, Ezequiel; PIRO, Oscar E.; CASTELLANO, Eduardo Ernesto; PETROSELLI, Gabriela; ERRA-BALSELLS, Rosa; CABRERIZO, Franco M.; RUIZ, Gustavo T.},title={Synthesis, structural characterization and biological evaluation of rhenium(I) tricarbonyl complexes with b-carboline ligands},journal={Chemistry Select},note={v. 2, n. 27, p. 8666-8672},year={2017}} |