Oxime-derived palladacycles bearing 2,6-lutidine: synthesis, cytotoxicity evaluation and interactions with biomolecules.
POLEZ, Ana Maria Romão; FARIAS, Renan Lira de; LIMA, Andresa Alves de; LAZZARINI, Ana Beatriz; MOURA, Thales Reggiani de; VELASQUES, Jecika Maciel; SOUZA, Jessica Carolina; ROCHA, Fillipe Vieira; LIMA, Mauro Almeida; ELLENA, Javier; MIRANDA, Victor Maia; DEFLON, Victor Marcelo; MOREIRA, Mariete Barbosa; NETTO, Adelino Vieira de Godoy.
POLEZ, Ana Maria Romão; FARIAS, Renan Lira de; LIMA, Andresa Alves de; LAZZARINI, Ana Beatriz; MOURA, Thales Reggiani de; VELASQUES, Jecika Maciel; SOUZA, Jessica Carolina; ROCHA, Fillipe Vieira; LIMA, Mauro Almeida; ELLENA, Javier; MIRANDA, Victor Maia; DEFLON, Victor Marcelo; MOREIRA, Mariete Barbosa; NETTO, Adelino Vieira de Godoy.
Abstract: In this study, we report the synthesis, characterization and biological studies on new organometallic compounds bearing orthopalladated oximes and 2,6-lutidine. Cyclopalladated compounds of the type [PdCl(C2,N-ox)(lut)] {ox: bzox = benzaldehydeoxime (1), aphox = acetophenoneoxime (2), tetrox = E-a-tetralone oxime (3); lut = 2,6-lutidine} have been obtained from the reaction between the suitable [Pd(C2,N-ox)(µ-Cl)]2 precursor with 2,6-lutidine. The compounds have been characterized by elemental analyses, infrared (IR) and NMR spectroscopies. The molecular and crystal structures of 1 - 3 have been determined by single-crystal X-ray crystallography. The cytotoxic activity of compounds 1-3 has been evaluated towards breast (MCF-7 and MD-MBA-231) and lung (A549) human cancer cells along with human lung fibroblast (MRC-5). The level of cytotoxicity is dependent on the tested tumour cell line and the type of orthometallated oxime. The binding properties of the model compound 3 on ct-DNA have been studied using UV?Vis titration, circular dichroism and fluorescence spectroscopy.
@article={003216816,author = {POLEZ, Ana Maria Romão; FARIAS, Renan Lira de; LIMA, Andresa Alves de; LAZZARINI, Ana Beatriz; MOURA, Thales Reggiani de; VELASQUES, Jecika Maciel; SOUZA, Jessica Carolina; ROCHA, Fillipe Vieira; LIMA, Mauro Almeida; ELLENA, Javier; MIRANDA, Victor Maia; DEFLON, Victor Marcelo; MOREIRA, Mariete Barbosa; NETTO, Adelino Vieira de Godoy.},title={Oxime-derived palladacycles bearing 2,6-lutidine: synthesis, cytotoxicity evaluation and interactions with biomolecules},journal={Journal of Molecular Structure},note={v. 1321, Part 5, p. 140232-1-140232-11},year={2025}}