Abstract – Publication

Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and ß-lapachone.
MARANGONI, Valeria S.; BERNARDI, Juliana Cancino; REIS, Ianny B.; FÁVARO, Wagner J.; ZUCOLOTTO, Valtencir.
Abstract: Plasmonic gold nanoparticles present extraordinary potential for near-infrared photothermal and triggered-therapeutic release treatments of solid tumors. In this study, we create a multifunctional nanocarrier in which PEG-coated gold nanorods are grouped into natural cell membrane vesicles (CM) from lung cancer (A549) cells and loaded with ß-lapachone (CM-ß-Lap-PEG-AuNRs). ß-Lapachone (ß-Lap) is an anticancer agent activated by the enzyme NADP(H):quinine oxidoreductase (NQO1), commonly found at higher levels in cancer cells. The irradiation with near-infrared (NIR) laser leads to disruption of the vesicles and release of the PEG-AuNRs and ß-Lap. The system presents an enhanced in vitro cytotoxicity against A549 cancer cells, which can be attributed to the specific cytotoxicity of ß-Lap combined with heat generated by laser irradiation of the AuNRs. In agreement, in vivo treatment with CM-ß-Lap-PEG-AuNRs and irradiation shows a histopathological recovery from nonmuscle invasive bladder cancer of most of the animals with only one cycle of application and irradiation. Such multifunctional platform is a promissing candidate for improved activated drug release and phototherapy.
ACS Applied Bio Materials
v. 2, n. 2, p. 728-736 - Ano: 2019
http://dx.doi.org/10.1021/acsabm.8b00603
    @article={002941992,author = {MARANGONI, Valeria S.; BERNARDI, Juliana Cancino; REIS, Ianny B.; FÁVARO, Wagner J.; ZUCOLOTTO, Valtencir.},title={Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and ß-lapachone},journal={ACS Applied Bio Materials},note={v. 2, n. 2, p. 728-736},year={2019}}

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