Picraviane A and B: nortriterpenes with limonoid-like skeletons containing a heptanolide e-ring system from Picramnia glazioviana.
GIMENES, Leila; BATISTA JUNIOR, Joao Marcos; SANTOS JUNIOR, Fernando Martins dos; SOUZA, Matheus da Silva; LUNA-DULCEY, Liany; ELLENA, Javier; COMINETTI, Marcia Regina; SILVA, Maria Fatima das Graças Fernandes da; VIEIRA, Paulo Cezar; FERNANDES, João Batista; STAERK, Dan.
GIMENES, Leila; BATISTA JUNIOR, Joao Marcos; SANTOS JUNIOR, Fernando Martins dos; SOUZA, Matheus da Silva; LUNA-DULCEY, Liany; ELLENA, Javier; COMINETTI, Marcia Regina; SILVA, Maria Fatima das Graças Fernandes da; VIEIRA, Paulo Cezar; FERNANDES, João Batista; STAERK, Dan.
 Abstract: Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. The absolute configuration of both compounds were assigned by comparison of experimental and calculated vibrational and electronic circular dichroism spectroscopy, respectively. Picraviane A showed a moderate cytotoxic activity against the triple negative MDA-MB-231 breast cancer cell line. These compounds represent an undescribed class of natural products with limonoid-like skeletons containing a heptanolide as the E-ring. | |
| Phytochemistry |
| v. 163, p. 38-45 - Ano: 2019 |
| Fator de Impacto: 3,186 |
| http://dx.doi.org/10.1016/j.phytochem.2019.03.024 |  @article={002938704,author = {GIMENES, Leila; BATISTA JUNIOR, Joao Marcos; SANTOS JUNIOR, Fernando Martins dos; SOUZA, Matheus da Silva; LUNA-DULCEY, Liany; ELLENA, Javier; COMINETTI, Marcia Regina; SILVA, Maria Fatima das Graças Fernandes da; VIEIRA, Paulo Cezar; FERNANDES, João Batista; STAERK, Dan.},title={Picraviane A and B: nortriterpenes with limonoid-like skeletons containing a heptanolide e-ring system from Picramnia glazioviana},journal={Phytochemistry},note={v. 163, p. 38-45},year={2019}} |
